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Decipher Prostate RP
Test Report Overview

We want you to feel confident in every treatment decision you make using Decipher Prostate for your patients with prostate cancer, beginning with a clear understanding of how to interpret the key components of the RP test report.

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Page 1 contains the Decipher Score, risk estimates, and an interpretation of the score.

RP Report Guide Page 1 1

1. Dynamic Report

The report is tailored to the clinical presentation of this patient

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2. Decipher Score

  • Reflects genomic risk of metastasis
  • Determined by tumor biology alone, independent of clinical & pathological factors (e.g., Gleason, PSA)
  • 22 genes, 7 biological pathways
  • Continuous genomic risk score classified as low, intermediate or high
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3. Interpretation

Summary based on this patient’s genomic risk & relevant clinical findings

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4. Risk Estimates

  • Calibrated to outcomes of patients after surgery with undetectable, persistently-elevated, or rising PSA
    • Metastasis at 5 & 10 years
    • Prostate Cancer Mortality at 15 years

Page 2 contains case analysis, interpretation, and clinical findings.

RP Report Guide Page 2 5

5. Interpretation

  • Explains risk comparison graphic
  • Provides this patient’s percentile rank in the tested population
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6. Risk Comparisons 

  • This patient’s 10-year risk of metastasis with respect to 3,013 other patients with Gleason 4+3=7 disease & rising PSA
  • The distribution of Decipher risk within the 3,013 patients is:
    • 19% Decipher Low
    • 16% Decipher Int.
    • 65% Decipher High
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7. Treatment Graphics

  • Treatment Timing (Left)
    • Risk of metastasis after post-RP radiation stratified by Decipher risk & PSA level at time of treatment
  • Treatment Intensity (Right)
    • Risk of receiving salvage ADT after radiation alone stratified by Decipher risk & PSA level at time of treatment
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8. Clinical Findings

Clinical study results relevant to this patient

Page 3 contains a test description, intended use info, confidence intervals, and references.

RP Report Guide Page 3 9

9. Test Description

  • Description of:
    • Decipher testing platform technology
    • Risk estimates
    • Cut-points separating Decipher low, intermediate & high
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10. Intended Use

Decipher Prostate RP is intended for use in post-RP specimens from localized prostate cancer patients with undetectable, persistent, or rising PSA

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11. Confidence Intervals

The 95% confidence intervals for each risk estimate (on page 1)

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12. References

For each of the clinical studies cited in the report