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Decipher Prostate RP Genomic Classifier

The Decipher Prostate RP Genomic Classifier
test report overview can help you understand
components of the test report.

Home > Decipher Prostate > Physicians > RP Test Report Guide

Page 1 contains the Decipher Score, risk estimates, and an interpretation of the score.

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1. Decipher Score

  • Determined by tumor biology alone, not influenced by clinicopathologic variables (e.g., Gleason, PSA)
  • 22 genes, 7 biological pathways
  • Continuous genomic risk score
  • 3 categories of risk (low, intermediate, or high)
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2. Risk Estimates

  • Prostate cancer risk estimates were determined by numerical integration of >30,000 prostate cancer patients with available Decipher scores calibrated to >25,000 patients with long-term follow-up and from published meta-analyses.
  • Risk of 5- & 10-year metastasis and 15-year prostate cancer mortality after radical prostatectomy.
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3. Interpretation

Summary based on the patient’s Decipher score & relevant clinical findings from published studies including Decipher.

Page 2 contains case analysis, interpretation, and clinical findings.

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4. Dynamic Report

The report is tailored to the clinical presentation of the patient

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5. Risk Comparisons 

  • This patient’s 10-year risk of metastasis is compared to 987 patients with similar clinical features
  • For these patients, Decipher risk groups are distributed as:
    • 35% Low
    • 16% Intermediate
    • 49% High
  • Distribution of risk is dependent on clinical risk group
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6. Interpretation

  • Explains risk comparison graph
  • Specifies the percentile of risk for this patient 
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7. Treatment Graphics

  • Evidence from Decipher Prostate RP studies
  • Radiotherapy Timing (Left)
    • Risk of metastasis with post-RP radiotherapy is dependent on the Decipher score and PSA level at time of treatment
  • Treatment Intensity (Right)
    • Risk of progression to ADT after radiotherapy alone in conjunction with the Decipher score and PSA level can help with the hormone therapy decision
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8. Clinical Findings

Clinical study results relevant for the patient

Page 3 contains a test description, intended use info, confidence intervals, and references.

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9. Test Description

  • How the test is performed
  • Definitions for each of the endpoints reported
  • Provides detail on the cut-points for Decipher risk groups
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10. Intended Use

Decipher Prostate RP is intended for use in men with localized prostate cancer after surgery with undetectable, persistent, or rising PSA

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11. Confidence Intervals

The 95% confidence interval for each endpoint reported

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12. References

For each of the clinical studies cited in the report